Key active sites of proteases and protease inhibitors: a review / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 561-579, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-878582
ABSTRACT
Proteases are widely found in organisms participating in the decomposition of proteins to maintain the organisms' normal life activities. Protease inhibitors regulate the activities of target proteases by binding to their active sites, thereby affecting protein metabolism. The key amino acid mutations in proteases and protease inhibitors can affect their physiological functions, stability, catalytic activity, and inhibition specificity. More active, stable, specific, environmentally friendly and cheap proteases and protease inhibitors might be obtained by excavating various natural mutants of proteases and protease inhibitors, analyzing their key active sites by using protein engineering methods. Here, we review the studies on proteases' key active sites and protease inhibitors to deepen the understanding of the active mechanism of proteases and their inhibitors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptido Hidrolasas
/
Endopeptidasas
/
Inhibidores de Proteasas
/
Sitios de Unión
/
Proteínas
/
Dominio Catalítico
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2021
Tipo del documento:
Artículo
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