Pathway design and key enzyme analysis of diosgenin biosynthesis / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1178-1188, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-878623
ABSTRACT
As a naturally occurring steroid sapogenin, diosgenin acts as the precursor of hundreds of steroid medicines, and thereby has important medicinal value. Currently, industrial production of diosgenin relies primarily on chemical extraction from plant materials. Clearly, this strategy shows drawbacks of excessive reliance on plant materials and farmland as well as environment pollution. Due to development of metabolic engineering and synthetic biology, bio-production of diosgenin has garnered plenty of attention. Although the biosynthetic pathways of diosgenin have not been completely identified, in this review, we outline the identified biosynthetic pathways and key enzymes. In particular, we suggest heterologous biosynthesis of diosgenin in Saccharomyces cerevisiae. Overall, this review aims to provide valuable insights for future complete biosynthesis of diosgenin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Diosgenina
/
Vías Biosintéticas
/
Ingeniería Metabólica
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2021
Tipo del documento:
Artículo
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