Clinical significance of minimal residual disease in B-lineage acute lymphoblastic leukemia pediatric patients with different fusion gene backgrounds / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 1279-1285, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-879790
ABSTRACT
OBJECTIVE@#To study the clinical significance of minimal residual disease (MRD) in B-lineage acute lymphoblastic leukemia (B-ALL) pediatric patients with different fusion gene backgrounds.@*METHODS@#A retrospective analysis was performed on the medical data of 441 B-ALL children who were treated from January 2008 to April 2015. Among the 441 children, 336 had negative fusion gene, 79 had positive @*RESULTS@#In patients with negative fusion gene, the positive MRD group had significantly lower overall survival (OS) rate and event-free survival (EFS) rate (@*CONCLUSIONS@#MRD has the most definite prognostic significance in pediatric B-ALL patients with negative fusion gene, while it has unsatisfactory prognostic significance in those with positive
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras B
/
Proteínas de Fusión Oncogénica
/
Estudios Retrospectivos
/
Neoplasia Residual
/
Proteínas de Homeodominio
/
Supervivencia sin Enfermedad
/
Subunidad alfa 2 del Factor de Unión al Sitio Principal
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2020
Tipo del documento:
Artículo
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