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A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019 / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 1344-1348, 2020.
Artículo en Chino | WPRIM | ID: wpr-879800
ABSTRACT
With the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) all over the world, there is an increasing number of children with such infection. Angiotensin-converting enzyme 2 (ACE2), one of the binding sites for SARS-CoV-2 infection in humans, can bind to viral spike proteins, allowing transmembrane serine protease (TMPRSS2) to activate S-protein to trigger infection and induce the production of various inflammatory factors such as interleukin-1, interferon-l, and tumor necrosis factor. Compared with adults, children tend to have lower expression levels of ACE2 and TMPRSS2, which are presumed to be associated with milder symptoms and fewer cases in children. The article summarizes the research advances in the role of ACE2 during SARS-CoV-2 infection, in order to help understand the pathogenic mechanism of SARS-CoV-2 and provide a reference for better development of drugs and vaccines to prevent and treat coronavirus disease 2019 in children.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Receptores Virales / Serina Endopeptidasas / Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / COVID-19 Límite: Niño / Humanos Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2020 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Receptores Virales / Serina Endopeptidasas / Enzima Convertidora de Angiotensina 2 / SARS-CoV-2 / COVID-19 Límite: Niño / Humanos Idioma: Chino Revista: Chinese Journal of Contemporary Pediatrics Año: 2020 Tipo del documento: Artículo