Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1399-1405, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-880776
ABSTRACT
OBJECTIVE@#To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.@*METHODS@#Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the @*RESULTS@#In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (@*CONCLUSIONS@#Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fenantrenos
/
Ratas Sprague-Dawley
/
Diterpenos
/
Compuestos Epoxi
/
Furanos
/
Glucósidos
/
Riñón
/
Antiinflamatorios
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2020
Tipo del documento:
Artículo
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