Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1622-1627, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-880783
ABSTRACT
OBJECTIVE@#To investigate the expression of CDC25A in non- small cell lung cancer (NSCLC) tissues and explore its correlation with the clinicpathological features of the patients and the expressions of let-7a1 and let-7c.@*METHODS@#We collected surgical specimens of pathologically confirmed NSCLC tissues and paired adjacent lung tissues from 44 patients and tissues of benign lung lesions from 9 patients. The expressions of CDC25A protein and mRNA in the tissues were detected by immunohistochemistry and fluorescence quantitative RT-PCR, respectively; the expressions of let-7a1 and let-7c mRNA were detected using tail-adding fluorescence quantitative RT-PCR.@*RESULTS@#The positivity rate of CDC25A protein expression was significantly higher in NSCLC tissues than in the adjacent tissues and benign pulmonary lesions (@*CONCLUSIONS@#The expression level of CDC25A is significantly increased in NSCLC with a negative correlation with Let-7c expression, which identifies CDC25A as a possible downstream target gene of Let-7c.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ARN Mensajero
/
Regulación Neoplásica de la Expresión Génica
/
Carcinoma de Pulmón de Células no Pequeñas
/
Fosfatasas cdc25
/
MicroARNs
/
Pulmón
/
Neoplasias Pulmonares
/
Metástasis Linfática
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Southern Medical University
Año:
2020
Tipo del documento:
Artículo
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