Advances on immune-related adverse events associated with immune checkpoint inhibitors / 医学前沿
Frontiers of Medicine
;
(4): 33-42, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-880945
ABSTRACT
Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitors (ICIs) are the most successful agents approved for multiple advanced malignancies. However, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associated with a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems. Up to 90% of patients who received ICIs combination therapy experienced irAEs, of which majority were low-grade toxicity. Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors usually display distinct features of irAEs. In this review, the mechanisms of action of ICIs and how they may cause irAEs are described. Some unsolved challenges, however really engrossing issues, such as the association between irAEs and cancer treatment response, tumor response to irAEs therapy, and ICIs in challenging populations, are comprehensively summarized.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Inhibidores de Puntos de Control Inmunológico
/
Inmunoterapia
/
Neoplasias
/
Antineoplásicos
Límite:
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS