Preparation and evaluation of a water-in-oil nanoemulsion drug delivery system loaded with salidroside / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 231-240, 2021.
Article
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| WPRIM
| ID: wpr-881067
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WPRO
ABSTRACT
Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this study was to develop and optimize a water-in-oil nanoemulsion of SAL (w/o SAL-N) to explore its suitability in oral drug delivery systems. In this work, SAL-N was successfully prepared by water titration method at K
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Revista:
Chinese Journal of Natural Medicines (English Ed.)
Año:
2021
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Article