Injectable thermo-responsive nano-hydrogel loading triptolide for the anti-breast cancer enhancement

Yaoyao LUO; Jingjing LI; Yichen HU; Fei GAO; George PAK-HENG-LEUNG; Funeng GENG; Chaomei FU; Jinming ZHANG

Yaoyao LUO; Jingjing LI; Yichen HU; Fei GAO; George PAK-HENG-LEUNG; Funeng GENG; Chaomei FU; Jinming ZHANG.

Acta Pharmaceutica Sinica B ; (6): 2227-2245, 2020.

Article en En | WPRIM | ID: wpr-881108

Biblioteca responsable: WPRO

ABSTRACT

ABSTRACT

The clinical application of triptolide (TPL) in tumor therapy has been greatly limited by its toxicity and inefficient delivery. Herein, a localized and sustained-release thermo-sensitive hydrogel was developed for the intra-tumor administration of TPL. Based on the amphiphilic structure of poly (

Palabras clave

Anti-angiogenesis; Breast cancer; Micelle; Pro-apoptosis; Survival rate; Thermo-responsive hydrogel; Triptolide; Tumor local treatment

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Texto completo: 1 Índice: WPRIM Idioma: En Revista: Acta Pharmaceutica Sinica B Año: 2020 Tipo del documento: Article

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