Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension
Acta Pharmaceutica Sinica B
;
(6): 2339-2347, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-881115
ABSTRACT
Optimization efforts were devoted to discover novel PDE10A inhibitors in order to improve solubility and pharmacokinetics properties for a long-term therapy against pulmonary arterial hypertension (PAH) starting from the previously synthesized inhibitor
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Acta Pharmaceutica Sinica B
Año:
2020
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS