Discovery of novel diarylamides as orally active diuretics targeting urea transporters
Acta Pharmaceutica Sinica B
;
(6): 181-202, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-881132
ABSTRACT
Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics. In the present study, a novel UT inhibitor with a diarylamide scaffold was discovered by high-throughput screening. Optimization of the inhibitor led to the identification of a promising preclinical candidate,
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Acta Pharmaceutica Sinica B
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS