Gene deficiency or pharmacological inhibition of PDCD4-mediated FGR signaling protects against acute kidney injury
Acta Pharmaceutica Sinica B
;
(6): 394-405, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-881143
ABSTRACT
Recent studies have shown that programmed cell death 4 (PDCD4) modulates distinct signal transduction pathways in different pathological conditions. Despite acute and chronic immune responses elicited by ischemia contributing to the functional deterioration of the kidney, the contributions and mechanisms of PDCD4 in acute kidney injury (AKI) have remained unclear. Using two murine AKI models including renal ischemia/reperfusion injury (IRI) and cisplatin-induced AKI, we found that PDCD4 deficiency markedly ameliorated renal dysfunction and inflammatory responses in AKI mice. Consistently, upregulation of PDCD4 was also confirmed in the kidneys from patients with biopsy confirmed acute tubular necrosis from a retrospective cohort study. Moreover, we found that overexpression of
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio observacional
Idioma:
Inglés
Revista:
Acta Pharmaceutica Sinica B
Año:
2021
Tipo del documento:
Artículo
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