Comparison of Measles Specific IgG in the Sera of Infants and Children after Vaccination of Measles

ABSTRACT

PURPOSE: After recent epidemics of measles in Korea, Korean Pediatric Society recommended 2 dose measles vaccination schedule instead of 1 dose since 1991. However, the studies that supported the modification of vaccination schedule were insufficient yet. This study was performed to evaluate the vaccination efficacy of 1 dose and 2 dose vaccination. METHODS: One dose vaccination group consisted of 19 infants(mean 13.5 months of age) and two dose vaccination group consisted of 17 infants(mean 20.4 months of age). We measured the serum level of measles specific IgG antibody in vaccinated infants during 2 to 8month after vaccination using enzyme linked immunosorbent assay(ELISA). RESULTS: 1) There was no significant difference between one dose and two dose vaccination group in measles specific IgG antibody level(479+/-203AU/ml vs. 442+/-119AU/ml). 2) There was no significant difference between one dose and two dose vaccination in seropositivity of measles specific IgG antibody(94.7% vs. 88.2%). 3) Seropositivity of measles specific IgG antibody in all subjects has gradually decreased after vaccination and it was not related to the dose of vaccination. CONCLUSIONS: These results suggest that two dose vaccination of measles is not effective than one dose. Therefore, to confirm the current vaccination schedule of measles in Korea, more studies about effective method of vaccination should be performed.