Graft-Versus-Host Disease Limited to the Irradiated Skin
Annals of Dermatology
;
: 125-129, 1993.
Artículo
en Inglés
| WPRIM
| ID: wpr-88351
ABSTRACT
We present two very interesting cases of acute graft-versus-host disease (GVHD), whose skin rashes initially appeared on the localized area of total nodal irradiation (TNI) performed previously to prevent graft rejection and/or GVHD. The histopathologic findings showed some dyskeratotic cells in the epidermis and perivascular mononuclear cell infiltration in the upper dermis. The immunohistochemical studies revealed that HLA-DR was diffusely strongly positive in a number of keratinocytes, whereas both CD4 and CD8 were focally weakly positive in the perivascular lymphocytes in the upper dermis. Later on, liver dysfunction and diarrhea developed and skin rashes began to spread over the other parts of the body in those two patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Piel
/
Linfocitos
/
Antígenos HLA-DR
/
Queratinocitos
/
Dermis
/
Diarrea
/
Epidermis
/
Exantema
/
Rechazo de Injerto
/
Enfermedad Injerto contra Huésped
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
1993
Tipo del documento:
Artículo
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