Research progress on the association between radiation-induced lung injury and ferroptosis / 中华放射肿瘤学杂志
Chinese Journal of Radiation Oncology
; (6): 527-530, 2021.
Article
en Zh
| WPRIM
| ID: wpr-884601
Biblioteca responsable:
WPRO
ABSTRACT
Radiation-induced lung injury (RILI) is a common complication after radiotherapy for lung cancer and alternative thoracic malignant tumors, while ferroptosis is a regulated cell death triggered by iron-dependent membrane lipid peroxidation. In this article, the relationship between RILI and ferroptosis was investigated from oxidative damage induced by reactive oxygen species, antioxidant network and iron homeostasis regulated by nuclear factor erythroid 2-related factor 2(Nrf2) as well as transforming growth factor involved in the inflammatory response, aiming to mitigate or inhibit the occurrence of RILI through regulating ferroptosis, thereby improving clinical prognosis of patients undergoing radiotherapy.
Texto completo:
1
Índice:
WPRIM
Tipo de estudio:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Radiation Oncology
Año:
2021
Tipo del documento:
Article