Association of abnormal glucose regulation with subclinical carotid atherosclerosis in the healthy / 中华健康管理学杂志

ABSTRACT

Objective:To investigate the association of Subclinical Carotid AtheroSclerosis (SCAS) and prediabetes or Diabetes Mellitus (DM)in the healthy people.Methods:From September 2018 to June 2019, participants who underwent physical examination in the Health Management Center of Beijing Tiantan Hospitial were enrolled consecutively. The baseline characters were collected prospectively. Carotid Ultrasound was evaluated by radiologists according to the standard operating protocol. Univariable analysis and multivariable logistic analysis were used to estimate the association of prediabetes or DM with SCAS.Results:Totally 401 participants were eligible and enrolled. The mean age was (52.2±10.4) years and 43.7% (252/401) of them were females. The prevalence of DM and SCAS were 16.4% (66/401) and 48.9% (196/401) respectively. In the univariate analysis, elder age (≥60 years old) ( OR=5.93, 95% CI 3.86-9.09, P<0.001), hypertension ( OR=2.76, 95% CI 1.84-4.15, P<0.01), prediabetes( OR=1.67, 95% CI 1.08-2.58, P<0.05) and DM ( OR=3.60, 95% CI 1.97-6.58, P<0.01), cigarettes smoking ( OR=2.64, 95% CI 1.82-3.81, P<0.001), lower HDLlevel<1.04 mmol/L ( OR=1.58, 95% CI 1.04-2.42, P<0.001) and hyperhomocysteinemia (≥15 μmol/L)( OR=1.69, 95% CI 1.17-4.04, P<0.01) were associated with higher prevalence of SCAS. On the contrary, female sex ( OR=0.53, 95% CI 0.39-0.74, P<0.001) was associated with lower prevalence of SCAS. In the multivariable logistic analysis, elder age(≥60 years old) ( OR=6.04, 95% CI 3.13-11.7, P<0.01), hypertension ( OR=2.14, 95% CI 1.13-3.87, P<0.05), cigarettes smoking ( OR=2.19, 95% CI 1.21-3.98, P<0.05) and DM ( OR=2.32, 95% CI 1.16-4.67, P<0.05) were associated with SCAS independently. The association between prediabetes and SCAS was not statistically significant. Conclusions:DM is independently associated with SCAS in neurological healthy people, while prediabetes tended to increase the risk of SCAS.