Programmed cell death 1 and T lymphocyte immunity in chronic obstructive pulmonary disease / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
; (12): 237-241, 2021.
Article
en Zh
| WPRIM
| ID: wpr-885664
Biblioteca responsable:
WPRO
ABSTRACT
T lymphocyte immune dysfunction plays an important role in the occurrence and development of chronic obstructive pulmonary disease (COPD), but the specific mechanism is not fully understood. Programmed cell death 1 (PD-1) negatively regulates the activation and effector function of T lymphocytes by binding to its ligand PD-L1, thus participating in the maintenance of immune tolerance. Recent studies have found that blocking the PD-1/PD-L1 signaling pathway can improve T-cell depletion and enhance the ability of anti-infection in COPD patients. Therefore, understanding the regulatory effects of PD-1 on T lymphocytes is of great significance to studying the pathogenesis and clinical treatment of COPD. This article briefly reviewed the research progress in PD-1 in terms of structure, function, T cell regulation and relationship with COPD.
Texto completo:
1
Índice:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Microbiology and Immunology
Año:
2021
Tipo del documento:
Article