Progress of biological functions and molecular mechanisms of long non-coding RNA Foxf1 adjacent non-coding developmental regulatory RNA in malignant tumors / 肿瘤研究与临床

ABSTRACT

In recent years, the morbidity and mortality of malignant tumors in China have been increased year by year, which has caused a serious economic burden on families and society. Therefore, researches of the mechanism of cancer development and new methods of diagnosis and treatment are desperately needed. Foxf1 adjacent non-coding developmental regulatory RNA (FENDRR) is a long non-coding RNA (LncRNA) discovered in recent years. Its abnormal expression can regulate cell proliferation, migration and invasion through different mechanisms, and participate in the development of various malignant tumors. This article reviews the progress of biological functions and molecular mechanisms of FENDRR in different malignancies.