The Effects of Beta-Radiation Using a Holmium-166 Coated Balloon on Neointimal Hyperplasia in a Porcine Coronary Stent Restenosis Model
Korean Circulation Journal
;
: 398-406, 2002.
Artículo
en Coreano
| WPRIM
| ID: wpr-88673
ABSTRACT
BACKGROUND AND OBJECTIVES:
Brachytherapy is a promising method in the prevention and treatment of coronary stent restenosis. We sought to observe the therapeutic effects of a radioactive balloon loaded with Holmium-166 (166Ho) in a porcine coronary stent restenosis model. Materials andMethods:
A radioisotope of (166Ho) was coated on the balloon surface using a polyurethane coating (20 Gy in 0.5 mm depth). Stent overdilation injuries were performed in two coronary arteries in 8 pigs. Four weeks after the stent overdilation injury, radiation therapies were performed using a control balloon dilation in one coronary artery (Group In = 8) and a 166Ho-coated balloon in the other coronary artery in each pig (Group IIn = 8). Follow-up coronary angiogram and histopathologic assessment were performed at 4 weeks after the therepy was administered.RESULTS:
Laboratory findings did not differ significantly between the pre-treatment baseline and the measurements taken after radiation. On quantitative coronary angiogram, the coronary artery diameters were not significantly different between the two groups before stenting or at 4 and 8 weeks after stenting. On histopathologic analysis, injury score, internal elastic lamina area and lumen area did not differ significantly between the two groups. The neointimal area was 1.78 +/- 0.11 mm2 in group I and 1.36 +/- 0.12 mm2 in group II (p=0.017), and the histopathologic area of stenosis was 35.1 +/- 1.6% in Group I, 27.6 +/- 1.9% in Group II (p=0.005).CONCLUSION:
A treatment of beta-radiation in a stented porcine coronary artery using radioactive Ho-166 coated balloon inhibits stent restenosis without any side effects.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliuretanos
/
Traumatismos por Radiación
/
Radioisótopos
/
Porcinos
/
Braquiterapia
/
Stents
/
Estudios de Seguimiento
/
Constricción Patológica
/
Enfermedad Coronaria
/
Vasos Coronarios
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Idioma:
Coreano
Revista:
Korean Circulation Journal
Año:
2002
Tipo del documento:
Artículo
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