Correlation between serum 25 (OH) d level and metabolic indexes in elderly patients with diabetes mellitus / 公共卫生与预防医学

ABSTRACT

Objective To study correlation between serum 25 (OH) d level and metabolic indexes in elderly patients with diabetes mellitus. Methods In this prospective study, 315 elderly patients with diabetes who were diagnosed and treated in our hospital from January 2018 to June 2020 were selected as the research objects, and 100 healthy volunteers in the same period were selected as the control group. The blood lipid, fasting blood glucose (FPG), fasting insulin (fins), glycosylated hemoglobin (HbA1c) and insulin resistance (HOMA) of the two groups were analyzed- The levels of FPG, fins, GHbA1c, HOMA-IR and homa-is in patients with 25 (OH) D deficiency of different severity were compared, and the correlation between serum 25 (OH) d level and metabolic indexes was studied. Results The serum 25 (OH) d level of the observation group was significantly lower than that of the control group (t = 6.080, P = 0.000); the FPG (t = 14.708, P = 0.000), GHbA1c (t = 7.165, P = 0.000), HOMA-IR (t = 8.880, P = 0.000) of the observation group were significantly higher than those of the control group, homa-is (t = 120.847, P = 0.000), fins (t = 120.847, P = 0.000)= The levels of FPG (F = 12.334, P = 0.000), fins (F = 11.897, P = 0.000), GHbA1c (F = 10.090, P = 0.000), HOMA-IR (F = 11.232, P = 0.000) and homa-is (F = 9.009, P = 0.000) were not significantly different between the two groups (P < 0.05) FPG, GHbA1c, HOMA-IR of patients from high to low were deficiency group, deficiency group and sufficiency group, fins, homa-is levels from high to low were sufficiency group, deficiency group and deficiency group; through correlation analysis, serum 25 (OH) d levels of patients were negatively correlated with FPG, GHbA1c, HOMA-IR, and positively correlated with fins, homa-is. Conclusion The level of serum 25 (OH) d in elderly patients with diabetes is significantly correlated with metabolic indexes, which can become one of the important evaluation indexes of treatment effect in the future.