Effect of piceatannol against malignant melanoma / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 413-418, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-887752
ABSTRACT
OBJECTIVES@#To study the antitumor effect of piceatannol (PIC) on malignant melanoma @*METHODS@#B16F10 cells were cultured @*RESULTS@#The cell viability of B16F10 decreased with increasing PIC concentration. The results of the Transwell assay showed that invasion ability decreased with increasing PIC concentration, and healing time was prolonged at increased PIC concentration in the wound healing assay. Western blot results showed that PIC mainly inhibited the phosphorylation of Syk and inhibited the expression of MMP-2, MMP-9, and VEGF. RNA interference pointed out that blocking the expression of Syk can reveal the same inhibition effect on B16F10 cells as PIC. @*CONCLUSIONS@#PIC might block the progression of malignant melanoma by inhibiting spleen tyrosine kinase.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estilbenos
/
Movimiento Celular
/
Metaloproteinasa 2 de la Matriz
/
Metaloproteinasa 9 de la Matriz
/
Línea Celular Tumoral
/
Factor A de Crecimiento Endotelial Vascular
/
Quinasa Syk
/
Melanoma
/
Invasividad Neoplásica
Límite:
Animales
Idioma:
Inglés
Revista:
West China Journal of Stomatology
Año:
2021
Tipo del documento:
Artículo
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