Roles of Myeloid-derived Suppressor Cells in Breast Cancer Metastasis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 445-451, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-887878
ABSTRACT
Breast cancer patients with bone,liver and lung metastases tend to have a poor prognosis.According to Paget's "seed and soil" theory,metastatic cancer cell "seeds" must fall on congenial target organ "soil".Studies have shown that myeloid-derived suppressor cells(MDSCs)can be recruited at the site of breast cancer metastasis in advance and play a role in the metastasis of breast cancer cells.This paper reviews the biological characteristics of MDSCs,the roles of MDSCs in peripheral circulation,prometastatic niche,and metastatic site during breast cancer metastasis,as well as the research progress of MDSCs-targeted treatment of breast cancer metastasis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias de la Mama
/
Microambiente Tumoral
/
Células Supresoras de Origen Mieloide
/
Neoplasias Pulmonares
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
Idioma:
Chino
Revista:
Acta Academiae Medicinae Sinicae
Año:
2021
Tipo del documento:
Artículo
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