Current advances in research of semaphorin 3A:a potential target for the treatment of nospecific low back pain / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 589-592, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-888320
ABSTRACT
Nonspecific low back pain is closely associated with afferent nerve ingrowth into degenerated IVDs and increasing the inflammatory response. Members of the class 3 semaphorins signal their response through two prominent receptors; the NRP (Neuropilin-1) and the Plexin A. Sema3A (Semaphorin3A) is primarily known for their role in modulating neuronal survival as well as neurite outgrowth and guidance via regulation of Sema3A-NRP-1-plexinA signal pathway. Also, sema3A is shown to be conductive to innervate the inner painful degenerated IVDs (Intervertebral discs). Furthermore, sema3A is thought to act as a barrier to endothelial cells survival and migration on vascular endothelial growth factor (VEGF) and inhibition of KLF5-induced (Krüppel-like factor 5) inflammatory mediators within degenerated IVDs. Therefore, Sema3A produce a new perspective of dual-action therapeutic agent for attenuating the regulator of innervation and angiogenesis into degenerated IVDs and inhibition of KLF5-induced inflammation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Dolor de la Región Lumbar
/
Semaforina-3A
/
Neuropilina-1
/
Células Endoteliales
/
Factor A de Crecimiento Endotelial Vascular
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Humanos
Idioma:
Chino
Revista:
China Journal of Orthopaedics and Traumatology
Año:
2021
Tipo del documento:
Artículo
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