Research progress of necroptosis on bone related diseases / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 687-690, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-888340
ABSTRACT
As a new type of cell death, necroptosis is initiated by tumor necrosis factor receptor 1(TNFR1), and then activated receptor-interacting protein kinase 1(RIP1) and receptor-interacting protein kinase 3 (RIP3), following by the activation of mixed lineage kinase domain-like protein(MLKL) to deliver cell death signal. When necroptosis happens, damage associated molecular patterns (DAMPs) enter into extracellular area through the ruptured cytomembrane, followed by the disordered tissue hemeostasis. In recent years, many researches showed that necroptosis playimportant roles in a few bone related diseases, such as osteoporosis, osteonecrosis, osteosarcoma, etc. Thus, we try to briefly review the researches in this field.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Quinasas
/
Apoptosis
/
Necroptosis
Idioma:
Chino
Revista:
China Journal of Orthopaedics and Traumatology
Año:
2021
Tipo del documento:
Artículo
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