Role and mechanism of circular RNA in brain injury induced by inflammation in preterm mice: a preliminary study / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 730-734, 2021.
Artículo
en Chino
| WPRIM
| ID: wpr-888473
ABSTRACT
OBJECTIVE@#To determine the association of circular RNA (circRNA) and circRNA-microRNA (miRNA) network regulation with brain injury induced by inflammation in preterm mice.@*METHODS@#Pregnant mice were treated with intraperitoneally injected lipopolysaccharide to establish a preterm mouse model of brain injury induced by inflammation (inflammation preterm group with 3 mice). Preterm mice born to normal pregnant mice by cesarean section were selected as controls (non-inflammation preterm group with 3 mice). The gene microarray technique was used to screen out the circRNAs associated with brain injury in preterm mice. The miRNA target prediction software was used to predict the binding sites between circRNAs and miRNAs and analyze the regulatory mechanism.@*RESULTS@#A total of 365 differentially expressed circRNAs were screened out between the inflammation preterm and non-inflammation preterm groups (fold change > 1.5, @*CONCLUSIONS@#Inflammation induces a significant change in the expression profile of circRNAs in the brain tissue of mice, and the change in the expression of circRNAs plays an important role in brain injury induced by inflammation and subsequent brain development in preterm mice.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Lesiones Encefálicas
/
ARN
/
Cesárea
/
Perfilación de la Expresión Génica
/
MicroARNs
/
ARN Circular
/
Inflamación
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Embarazo
Idioma:
Chino
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2021
Tipo del documento:
Artículo
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