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Anti-inflammatory effects of Nelumbo leaf extracts and identification of their metabolites
Nutrition Research and Practice ; : 265-274, 2017.
Artículo en Inglés | WPRIM | ID: wpr-89160
ABSTRACT
BACKGROUND/

OBJECTIVES:

Nelumbo leaves have been used in traditional medicine to treat bleeding, gastritis, hemorrhoids, and halitosis. However, their mechanisms have not been elucidated. MATERIALS/

METHODS:

The present study prepared two Nelumbo leaf extracts (NLEs) using water or 50% ethanol. Inflammatory response was induced with LPS treatment, and expression of pro-inflammatory mediators (inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, and IL-6 and nitric oxide (NO) and prostaglandin E₂ (PGE₂) productions were assessed. To determine the anti-inflammatory mechanism of NLEs, we measured nuclear factor-κB (NF-κB) activity. Major metabolites of NLEs were also analyzed and quantified.

RESULTS:

NLEs effectively reduced the expression and productions of pro-inflammatory mediators such as IL-1β, IL-6, TNF-α, PGE₂, and NO. NLEs also reduced NF-κB activity by inhibiting inhibitor of NF-κB phosphorylation. Both extracts contained catechin and quercetin, bioactive compounds of NLEs.

CONCLUSIONS:

In this study, we showed that NLEs could be used to inhibit NF-κB-mediated inflammatory responses. In addition, our data support the idea that NLEs can ameliorate disease conditions involving chronic inflammation.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosforilación / Quercetina / Agua / Dinoprostona / Catequina / Interleucinas / Interleucina-6 / Óxido Nítrico Sintasa / Nelumbo / Etanol Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Idioma: Inglés Revista: Nutrition Research and Practice Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Fosforilación / Quercetina / Agua / Dinoprostona / Catequina / Interleucinas / Interleucina-6 / Óxido Nítrico Sintasa / Nelumbo / Etanol Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Idioma: Inglés Revista: Nutrition Research and Practice Año: 2017 Tipo del documento: Artículo