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Antibacterial Activity of an Antibiotic (K-681) from Streptomyces sp. 681 against Staphylococcus aureus
Journal of the Korean Society for Microbiology ; : 69-75, 1998.
Artículo en Coreano | WPRIM | ID: wpr-89386
ABSTRACT
The antimicrobial agents reduced infectious diseases significantly. However, antibiotic resistance has followed for almost every antimicrobial agent. Especially, Staphylococcus aureus was one of the most notorious for the multidrug resistance. Streptomyces sp. 681 has been selected for antibiotic-producing strain against methicillin-resistant Staphylococcus aureus (MRSA) from 1,000 strains of Actinomycetales which had been isolated from soil. In antimicrobial susceptibility test, all of the test strains were susceptible to vancomycin. However, most strains of Staphylococcus aureus were found to be resistant to methicillin. Ninety eight (75%) strains out of 129 strains showed multiple resistance pattern to more than 5 antimicrobial agents. The MIC values of the purified antibiotic (K-681) were 1-32 ug/ml against Gram-positive bacteria compared to >128 ug/ml against Grarn-negative bacteria or fungi. The MIC was 8 ug/ml for 90% of the 129 clinical isolates of S. aureus. The antibiotic showed no cytotoxicity against P 388, HeLa, and S180 at the concentration of 500 ug/ml.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Suelo / Staphylococcus / Staphylococcus aureus / Streptomyces / Bacterias / Actinomycetales / Farmacorresistencia Microbiana / Vancomicina / Enfermedades Transmisibles / Resistencia a Múltiples Medicamentos Idioma: Coreano Revista: Journal of the Korean Society for Microbiology Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Suelo / Staphylococcus / Staphylococcus aureus / Streptomyces / Bacterias / Actinomycetales / Farmacorresistencia Microbiana / Vancomicina / Enfermedades Transmisibles / Resistencia a Múltiples Medicamentos Idioma: Coreano Revista: Journal of the Korean Society for Microbiology Año: 1998 Tipo del documento: Artículo