Clinical Results in the Treatment of Extrahepatic Bile Duct Cancer and Long-term Survivors' Characteristics after Surgical Resection / 한국간담췌외과학회지

ABSTRACT

BACKGROUND/AIMS: The objectives of this study were to analyze actual long-term survivors' characteristics and investigate what affect long-term survival after resection for extrahepatic bile duct cancer. METHODS: 151 patients of the total 282 patients with extrahepatic bile duct cancer underwent surgical resection between 1986 and 1996. During study period, 23 cases of hepatobiliary resection (HBR), 25 bile duct resection (BDR), and 103 pancreatoduodenectomy were performed respectively. We analyzed survival results and prognostic factors after surgical resection. We also investigated clinico-pathological features of actual long-term survivors. RESULTS: The 1-,3-,and 5-year survival rates were 72.9%, 41.1%,and 32.5% in the resection group, and the 1-, 3-year survival rates were 35.4% and 1.6% in the non-resection group (p<0.001). The differences of survival rates according to the types of resection were not significant (p=0.083). After surgical resection, tumor histology and lymph node metastasis were the independent prognostic factors in multivariate analysis. CONCLUSION: The prognosis of the extrahepatic bile duct cancer depends on the curative resection. Regardless of the types of resection and tumor location, if tumor histology might be favorable and no lymph node metastasis exist, long-term survival could be expected.