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Prenatal Particulate Matter/Tobacco Smoke Increases Infants' Respiratory Infections: COCOA Study
Allergy, Asthma & Immunology Research ; : 573-582, 2015.
Artículo en Inglés | WPRIM | ID: wpr-89921
ABSTRACT

PURPOSE:

To investigate whether prenatal exposure to indoor fine particulate matter (PM2.5) and environmental tobacco smoke (ETS) affects susceptibility to respiratory tract infections (RTIs) in infancy, to compare their effects between prenatal and postnatal exposure, and to determine whether genetic factors modify these environmental effects.

METHODS:

The study population consisted of 307 birth cohort infants. A diagnosis of RTIs was based on parental report of a physician's diagnosis. Indoor PM2.5 and ETS levels were measured during pregnancy and infancy. TaqMan was used for genotyping of nuclear factor erythroid 2-related factor (Nrf2) (rs6726395), glutathione-S-transferase-pi (GSTP) 1 (rs1695), and glutathione-S-transferase-mu (GSTM) 1. Microarrays were used for genome-wide methylation analysis.

RESULTS:

Prenatal exposure to indoor PM2.5 increased the susceptibility of lower RTIs (LRTIs) in infancy (adjusted odds ratio [aOR]=2.11). In terms of combined exposure to both indoor PM2.5 and ETS, prenatal exposure to both pollutants increased susceptibility to LRTIs (aOR=6.56); however, this association was not found for postnatal exposure. The Nrf2 GG (aOR=23.69), GSTM1 null (aOR=8.18), and GSTP1 AG or GG (aOR=7.37) genotypes increased the combined LRTIs-promoting effects of prenatal exposure to the 2 indoor pollutants. Such effects of prenatal indoor PM2.5 and ETS exposure were not found for upper RTIs.

CONCLUSIONS:

Prenatal exposure to both indoor PM2.5 and ETS may increase susceptibility to LRTIs. This effect can be modified by polymorphisms in reactive oxygen species-related genes.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Padres / Infecciones del Sistema Respiratorio / Humo / Nicotiana / Cacao / Oportunidad Relativa / Estudios de Cohortes / Parto / Diagnóstico Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Humanos / Lactante / Embarazo Idioma: Inglés Revista: Allergy, Asthma & Immunology Research Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oxígeno / Padres / Infecciones del Sistema Respiratorio / Humo / Nicotiana / Cacao / Oportunidad Relativa / Estudios de Cohortes / Parto / Diagnóstico Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Factores de riesgo Límite: Humanos / Lactante / Embarazo Idioma: Inglés Revista: Allergy, Asthma & Immunology Research Año: 2015 Tipo del documento: Artículo