Differences in Body Weight, Dietary Efficiency, Brain Obesity Control Factor (AMPK), Reactive Oxygen Species (MDA), and Antioxidant Enzymes (SOD) in Young Mice According to the Intensity of Aerobic Exercise for 8 Weeks

ABSTRACT

Purpose@#The goal of this study was to see how different aerobic exercise intensities affected AMP-activated protein kinase (AMPK), reactive oxygen, and antioxidant enzymes in young mice during an 8-week period. @*Methods@#Forty male C57BL/6 mice, aged seven weeks, were randomly assigned to one of four groups control (n = 10), low-intensity exercise (n = 10), moderate-intensity exercise (n = 10), and high-intensity exercise (n = 10). For eight weeks, aerobic activity was performed once a day for 35–40 minutes, five days a week. The data were analyzed using descriptive statistics, analysis of variance (ANOVA), chi-squared tests, and the Tukey test in the SPSS/WIN 25.0 program. @*Results@#Weight (p = .001) was substantially different between the moderate-intensity exercise group and the control group in AMPK (p < .001). In addition, there were no significant differences between the moderate-intensity exercise group and the control group in reactive oxygen malondialdehyde (MDA) levels (p = .136) and antioxidant enzyme superoxide dismutase (SOD) levels (p = .521). @*Conclusion@#These findings suggest that moderate-intensity aerobic exercise increased AMPK activation and helped young mice shed weight.