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Pelvic Lymph Node Metastases in Prostate Cancer: Preoperative Detection With Dynamic Contrast-Enhanced Magnetic Resonance Imaging Compared With Postoperative Pathologic Result of Pelvic Lymph Node Dissection
Korean Journal of Urological Oncology ; : 158-164, 2017.
Artículo en Inglés | WPRIM | ID: wpr-90008
ABSTRACT

PURPOSE:

The aim of this study is evaluating the accuracy of preoperative magnetic resonance imaging (MRI) in patients who underwent pelvic lymph node dissection (PLND). MATERIALS AND

METHODS:

The medical records of 1,528 patients who underwent radical prostatectomy and PLND from 2003 to 2017 in Seoul National University Bundang Hospital were retrospectively reviewed. We evaluated the various clinicopathologic variables including preoperative MRI findings and pathologic lymph node (LN) metastasis. The prediction model for pathologic LN metastasis was assessed using univariate and multivariable logistic regression analyses and areas under receiver operating characteristic (ROC) curves.

RESULTS:

The mean age of our cohort was 66.4±6.7 years. Positive LN finding of preoperative MRI finding was observed in 9.4% (145 of 1,528) of patients. 5.3% (81 of 1,528) of patients had confirmed final pathologic LN metastases. Sensitivity and specificity of preoperative MRI were 30.8% and 91.7%, respectively. Multivariable analysis showed that preoperative MRI findings, clinical stage and biopsy Gleason score were independent significant predictors for pathologic LN metastasis (p < 0.001, p=0.002, and p < 0.001, respectively). Prediction model using preoperative MRI findings and National Comprehensive Control Network risk stratification showed fair accuracy using ROC analysis.

CONCLUSIONS:

Preoperative MRI findings for pathologic LN metastasis showed limited prediction value. A large-scale, multicenter, prospective study is needed to fully evaluate the clinical significance of preoperative MRI.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Biopsia / Imagen por Resonancia Magnética / Modelos Logísticos / Registros Médicos / Estudios Prospectivos / Estudios Retrospectivos / Curva ROC Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Urological Oncology Año: 2017 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Próstata / Prostatectomía / Neoplasias de la Próstata / Biopsia / Imagen por Resonancia Magnética / Modelos Logísticos / Registros Médicos / Estudios Prospectivos / Estudios Retrospectivos / Curva ROC Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de incidencia / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Korean Journal of Urological Oncology Año: 2017 Tipo del documento: Artículo