Importance of Early Diagnosis of Mycosis Fungoides Which Easily Overlooked with Benign Diseases: A Case Report / 대한피부과학회지

ABSTRACT

Mycosis fungoides is the most common form of cutaneous T-cell lymphoma. We report a case of MF patient who showed atypical histological findings. A 76 year-old Asian male patient visited our dermatology clinic with multiple skin lesions on the trunk since 2 years ago. Histopathological findings showed hyperchromatic enlarged atypical lymphocytes perivascular infiltration. Immuno-phenotyping showed numerous dermal lymphocytes with positive for CD3, 4, 8. In T-cell receptor gene rearrangement study, which revealed monoclonality. Patient was finally diagnosed with MF by confirming the monoclonality of the TCR gene rearrangement. The patient was treated with MTX, NBUVB therapy. Skin lesions were mostly improved and patient remained in good condition for 15 months without recurrence. Diagnosis of MF in early stages is important. Clinically, when encountering refractory erythematous plaques with peripheral rims, dermatologist should consider the possibility of MF and histologic remission of epidermis due to previous treatments.