Orthologous Allergens and Diagnostic Utility of Major Allergen Alt a 1
Allergy, Asthma & Immunology Research
;
: 428-437, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-90242
ABSTRACT
PURPOSE:
Hypersensitivity to fungi is associated with rhinoconjunctivitis and asthma. For some fungi, such as Alternaria alternata (A. alternata), the symptoms of asthma are persistent, increasing disease severity and the risk of fatal outcomes. There are a large number of species of fungi but knowledge of them remains limited. This, together with the difficulties in obtaining adequate standardized extracts, means that there remain significant challenges in the diagnosis and immunotherapy of allergy associated with fungi. The type of indoor fungi related to asthma/allergy varies according to geographic, climatic, and seasonal factors, making their study difficult. The aim of this study was to determine hypersensitivity to indoor fungi in a population from Cuenca, Spain.METHODS:
Thirty-five patients with symptoms compatible with rhinitis or asthma who showed clear worsening of their symptoms in their homes or workplace were included. In vivo and in vitro tests were made with a battery of fungal allergens, including the species isolated in the home or workplace.RESULTS:
Ulocladium botrytis (U. botrytis) and A. alternata were the most representative species as a source of home sensitization. These species showed very high concordance in skin tests, specific IgE, and histamine release. The allergen Alt a 1, which was recognized in all patients, was detected in A. alternata, U. botrytis, and Stemphylium botryosum (S. botryosum).CONCLUSIONS:
U. botrytis and A. alternata were the most representative species as a source of home sensitization. Alt a 1 was recognized in all patients and may be considered a non-species-specific allergen that could be used as a diagnostic source of sensitization to some species of the Pleosporaceae family.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Estaciones del Año
/
España
/
Técnicas In Vitro
/
Inmunoglobulina E
/
Pruebas Cutáneas
/
Alérgenos
/
Rinitis
/
Resultado Fatal
/
Botrytis
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
País/Región como asunto:
Europa
Idioma:
Inglés
Revista:
Allergy, Asthma & Immunology Research
Año:
2016
Tipo del documento:
Artículo
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