Changes in Liver Enzymes and Metabolic Profile in Adolescents with Fatty Liver following Exercise Interventions / 대한소아소화기영양학회지

ABSTRACT

Purpose@#Nonalcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver diseases in both adults and children with obesity. The aim of this study was to compare the changes in liver enzymes and metabolic profile in adolescents with fatty liver following selected school-based exercise (SBE) and high-intensity interval training (HIIT) interventions. @*Methods@#In a semi-experimental study, 34 obese male adolescents with clinically defined NAFLD were divided into the HIIT (n=11, age=12.81±1.02 years, body mass index [BMI]=26.68 ±2.32 kg/㎡ ), selected SBE (n=11, age=13.39±0.95 years, BMI=26.47±1.74 kg/㎡), and control (n=12, age=13.14±1.49 years, BMI=26.45±2.21 kg/㎡ ) groups. The ultrasonography NAFLD grade, peak oxygen uptake (VO 2peak ), lipid profile, insulin resistance, and alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels of the participants were measured before and after the exercise interventions. @*Results@#The BMI, waist-to-hip ratio, and body fat percentage of the participants decreased, and a significant increase in VO 2peak was observed after the intervention; however, the HIIT group showed a significant improvement compared with the SBE group (p0.01). @*Conclusion@#HIIT and SBE are equally effective in improving health parameters in obese children and adolescents.