Mucin histochemistry by paradoxical concanavalin A staining in early gastric carcinomas
Journal of Korean Medical Science
;
: 119-125, 1991.
Artículo
en Inglés
| WPRIM
| ID: wpr-90443
ABSTRACT
Phenotypic expression of tumor cells was investigated in 33 early gastric carcinomas by mucin histochemistry using paradoxical concanavalin A staining. This staining method had been developed to differentiate 3 classes of mucins located at various sites of the alimentary tract. Twenty-five (76%) tumors contained mixtures of neutral or acid class II mucin and class III mucin, suggesting the origin of multipotential stem cells. The surface mucous cell expression was more dominant than the pyloric gland or intestinal phenotypes in the well-and poorly differentiated adenocarcinomas. The intestinal properties of the tumor cells were noted not only in the well-differentiated but also in the poorly differentiated or signet ring cell carcinomas, not closely being related to the presence of background intestinal metaplasia. Signet ring cell carcinomas revealed a distinct pattern of mucin histochemistry compared with the other types.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Coloración y Etiquetado
/
Células Madre
/
Neoplasias Gástricas
/
Adenocarcinoma
/
Diferenciación Celular
/
Adenocarcinoma Mucinoso
/
Concanavalina A
/
Histocitoquímica
/
Intestinos
/
Metaplasia
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
1991
Tipo del documento:
Artículo
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