Association between microRNA-137 Gene Polymorphisms and Ischemic Post-stroke Depression / 中国康复理论与实践
Chinese Journal of Rehabilitation Theory and Practice
;
(12): 588-591, 2020.
Artículo
en Chino
| WPRIM
| ID: wpr-905484
ABSTRACT
Objective:
To analyze the relationship between microRNA-137 gene polymorphisms and ischemic post-stroke depression (PSD).Methods:
January, 2017 to January, 2019, the single nucleotide polymorphism (SNP) of rs1625579 in microRNA-137 was genotyped in 250 ischemic PSD patients and 250 healthy controls with SNaPshot. The expression of microRNA-137 was measured with quantitative real-time polymerase chain reaction in the mononuclear cells, and the association of the SNP rs1625579 with microRNA-137 expression was analyzed.Results:
The allele T was more in the patients than in the controls (OR = 2.033, 95%CI 1.255 to 3.294, P = 0.003), as well as the genotype TT (OR = 2.139, 95%CI 1.272~3.595, P = 0.004). The microRNA-137 expression was less in the patients than in the controls (t = 28.23, P < 0.001). For the controls, the microRNA-137 expression was also less in those with genotype of TT than with GT and GG (t = 3.764, P < 0.001).Conclusion:
The genotype TT of SNP rs1625579 in microRNA-137 is a risk factor of susceptibility to ischemic PSD, which may associate with the decrease of expression of microRNA-137.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Factores de riesgo
Idioma:
Chino
Revista:
Chinese Journal of Rehabilitation Theory and Practice
Año:
2020
Tipo del documento:
Artículo
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