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APE1/Ref-1 as a Serological Biomarker for the Detection of Bladder Cancer / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 823-833, 2015.
Artículo en Inglés | WPRIM | ID: wpr-90557
ABSTRACT

PURPOSE:

Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. MATERIALS AND

METHODS:

Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder cancer who had not received chemotherapy or radiotherapy (n=51) and non-tumor controls (n=55). The area under the receiver operating characteristic area under the curve was applied to determine the correlation between clinical factors and the serum levels of APE1/Ref-1.

RESULTS:

Serum levels of APE1/Ref-1 in bladder cancer patients were significantly elevated compared to those of the control group (3.548+/-0.333 ng/100 muL [n=51] for bladder cancer vs. 1.547+/-0.319 ng/100 muL [n=55] for the control group), with a sensitivity and specificity of 93% and 59%, respectively. Serum APE1/Ref-1 levels are associated with tumor stage, grade, muscle invasion, and recurrence.

CONCLUSION:

Serum APE1/Ref-1 might be useful as a potential serologic biomarker for bladder cancer.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radioterapia / Recurrencia / Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Ensayo de Inmunoadsorción Enzimática / Biomarcadores / Curva ROC / Sensibilidad y Especificidad / Quimioterapia Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Radioterapia / Recurrencia / Vejiga Urinaria / Neoplasias de la Vejiga Urinaria / Ensayo de Inmunoadsorción Enzimática / Biomarcadores / Curva ROC / Sensibilidad y Especificidad / Quimioterapia Tipo de estudio: Estudio diagnóstico / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Cancer Research and Treatment Año: 2015 Tipo del documento: Artículo