Modified Xiaoyao Erxian Decoction in Treatment of Mood Disorders in Perimenopausal Syndrome / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae
; (24): 144-149, 2021.
Article
en Zh
| WPRIM
| ID: wpr-905968
Biblioteca responsable:
WPRO
ABSTRACT
Objective:To observe the clinical efficacy of modified Xiaoyao Erxian decoction in the treatment of mood disorders among perimenopausal syndrome due to kidney deficiency and liver depression and its effects on monoamine neurotransmitters and brain-derived neurotrophic factor (BDNF). Method:According to the random number table, 108 patients were divided into a control group (54 cases) and an observation group (54 cases). Control group were treated with Shugan Jieyu capsule orally, two capsules per time, two times per day, while those in the observation group received the modified Xiaoyao Erxian decoction, one bag per day, for 12 consecutive weeks. Before and after treatment, the Hamilton Anxiety Scale (HAMA), 17-item Hamilton Depression Rating Scale (HAMD-17), modified Kupperman Index (KI), Pittsburgh Sleep Quality Index (PSQI), Menopause-specific Quality of Life (MENQOL) and kidney deficiency and liver depression syndrome scores were calculated. The levels of estradiol (E<sub>2</sub>), follicle-stimulating hormone (FSH), luteinizing hormone (LH), BDNF, 5-hydroxytryptamine (5-HT), norepinephrine (NE), and dopamine (DA) were detected, followed by safety evaluation. Result:The HAMA, HAMD-17, KI, kidney deficiency and liver depression syndrome, PSQI, and MENQOL scores of the observation group were lower than those of the control group (<italic>P</italic><0.01), whereas the 5-HT, E<sub>2</sub>, DA, NE, and BDNF levels in the observation group were higher (<italic>P</italic><0.01). The clinical efficacy of the observation group was superior to that in the control group (<italic>Z</italic>=2.184, <italic>P</italic><0.05). No adverse reactions occurred after the oral administration of Chinese medicinal preparations. Conclusion:The modified Xiaoyao Erxian decoction effectively alleviates the mood disorders and other related symptoms of perimenopausal syndrome due to kidney deficiency and liver depression by regulating the monoamine neurotransmitters, BDNF, and E<sub>2</sub>, without inducing obvious side effects.
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WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Experimental Traditional Medical Formulae
Año:
2021
Tipo del documento:
Article