Invasive Lobular Carcinoma: MRI Features and Clinicohistological Characteristics According to the ER, PR, and HER2 Statuses
Investigative Magnetic Resonance Imaging
;
: 137-145, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-90706
ABSTRACT
PURPOSE:
To investigate correlations of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor type 2 (HER2) statuses with magnetic resonance imaging (MRI) features and clinicohistological characteristics in patients with invasive lobular carcinoma (ILC). MATERIALS ANDMETHODS:
Data from 64 histologically confirmed ILCs were analyzed retrospectively. Preoperative breast MRI was reviewed for morphology and dynamic contrast-enhanced kinetics of the tumor. Pathologic reports were reviewed for ER, PR, and HER2 positivity, tumor size, lymph node metastasis, and the number of metastatic lymph nodes. Furthermore, there was an investigation of the MRI features and clinicohistologic characteristics, according to the ER, PR, and HER2 statuses.RESULTS:
A significant difference in MRI features and clinicohistological tumor characteristics were observed only in relation to PR status. Of the 64 ILCs, 10 (15.6%) were PR negative. PR negative cancers, compared with PR positive cancers, were more likely to present as non-mass enhancement (P = 0.027); have a significantly larger mean tumor size (5.00 +/- 1.05 cm vs. 2.57 +/- 0.21 cm, P = 0.021); and have significantly more metastatic lymph nodes (P = 0.010).CONCLUSIONS:
PR negative ILC presented more frequently as non-mass enhancement on MRI, with larger tumors and increased numbers of metastatic lymph nodes. Therefore, the PR status plays an important role in determining MRI features and clinicohistological characteristics of ILC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Mama
/
Imagen por Resonancia Magnética
/
Cinética
/
Receptores de Progesterona
/
Estudios Retrospectivos
/
Carcinoma Lobular
/
Estrógenos
/
Receptores ErbB
/
Ganglios Linfáticos
/
Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
Límite:
Humanos
Idioma:
Inglés
Revista:
Investigative Magnetic Resonance Imaging
Año:
2015
Tipo del documento:
Artículo
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