Updates on the role of T lymphocytes in crescentic glomerulonephritis / 国际儿科学杂志

ABSTRACT

The formation of crescent is a typical pathological change characterized by a rapid deterioration of renal function.T lymphocytes are involved in the formation of crescent and the pathological progression of crescent nephritis.CD4 + and CD8 + cells in T lymphocyte subsets, and T cell costimulatory factors mediate immune responses in different ways.They participate in the occurrence, development and fibrosis of crescent, or delay their deterioration.In order to provide a new target for clinical treatment of crescent nephritis, we review the mechanism of T lymphocytes in the formation and development of crescentic body.