Experimental research progress of acupuncture regulating apoptosis in the treatment of peripheral nerve injury / 国际中医中药杂志

ABSTRACT

Recently, acupuncture is the main treatment for peripheral nerve injury in animal experiments. The main diseases involved sciatic nerve injury, denervated skeletal muscle atrophy and diabetic peripheral neuropathy. Acupuncture can promote the regeneration and repair of peripheral nerve injury by regulating apoptosis, so as to improve the function of peripheral nerve. The mechanism is to regulate the apoptosis, Bcl-2 family, Caspase-3, Caspase-8, apoptotic factor-1 and the ligand expression, and regulate MAPK signal pathway and PI3K-Akt signaling pathway and endoplasmic reticulum stress pathway forinhibiting apoptosis.