Current status and prospects in surgical treatment of pancreatic neuroendocrine tumor with liver metastases / 中华内分泌外科杂志

ABSTRACT

Pancreatic neuroendocrine tumor (pNET) is a heterogeneous group of neoplasms that vary in their clinical presentation, biological behavior and prognosis. The most common site of metastasis is the liver. Surgical resection of both primary tumor and liver metastases is thought to have the best long-term outcomes by achieving a radical resection. The role of primary tumor resection in the setting of unresectable metastatic disease is controversial; However, more and more studies demonstrate an active cytoreductive surgery will benefit patients with a reasonable preoperative evaluation. For patients who are not surgical candidates, neoadjuvant therapy is attempted to find if it would downstage the tumor to regain the opportunity of R0 resection. Cytotoxic chemotherapy, targeted therapy, and PRRT present good treatment prospects, and further research is still needed. With multidisciplinary treatment, individualized protocol should provide patients a better treatment results.