Targeted temperature management of severe traumatic brain injury in children / 中国小儿急救医学

ABSTRACT

Traumatic brain injury(TBI) is one of leading causes of death and disability in children.Targeted temperature management(TTM) may reduce unfavorable outcomes of TBI patients, and many studies have made much effort for developing a norm in managing temperature in TBI patients.TTM, including therapeutic hypothermia, has been recognized as one of candidate methods of neuroprotective treatment.However, the efficacy of hypothermia for patients with severe TBI is not clear.In this article, we will review studies on the potential effects of hypothermia, discuss the possible pathophysiology of neuroprotection with therapeutic hypothermia in PICU, and explore the role of TTM in pediatric severe TBI.