Application of liquid chromatography-tandem mass spectrometry in the clinical diagnosis and treatment of adrenal incidentaloma / 中华检验医学杂志

ABSTRACT

With the development of diagnostic techniques, the diagnosis rate of adrenal incidental tumors is increasing. Disease related hormones can be detected to evaluate the endocrine function of tumors for diagnosis and treatment, especially by liquid chromatography-tandem mass spectrometry (LC-MS/MS). LC-MS/MS has the advantages of high sensitivity, specificity and multi-component, and has become the gold standard method for the detection of small molecule hormones.Mass spectrometry has advantages in the detection of glucocorticoids, halo corticoids, sex hormones and catecholamine metabolites.LC-MS/MS still has some limitations in clinical practice, which are manifested as low degree of automation and lack of standardization.After the improvement of the clinical application of LC-MS/MS and the establishment of reference scope, the clinical judgment on the endocrine function of AI will be more standardized.