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Proliferating Cell Nuclear Antigen Immunohistochemical Study in Melanocytic Skin Lesions / 대한피부과학회지
Korean Journal of Dermatology ; : 802-808, 1994.
Artículo en Coreano | WPRIM | ID: wpr-91482
ABSTRACT

BACKGROUND:

It is well-known that the giant congenital nevi prcgress to malignant, melanama more frequently than other benign melanocytic nevi but to date the laor tory methods for early detection of such progression were not avsilable. The proliferating cell uncleai antigen(PCNA) staining has been regsrded as an useful marker in determining prognosis of some maignant diseases.

OBJECTIVE:

The PCNA taining was performed as a predictive value of malignant transformation from benign meanocytic skin lesions. We investigated the differcnces between malignant melanoma and the benign lesions. MATERIAL AND

METHODS:

Immunohistochemical study was employee using anti-PCNA, anti-S-100, and anti-CD45RO antibody in 6 giant congenital nevi, 8 small and medium sized congenital nevi, 10 acquired nevi, and 10 malignant meanomas. Only cells positive for both PCNA and S-100, and negative for CD45RO on the serial sections were identified as melanocyts.

RESULTS:

The number of PCNA-posit,ive cells per 1000 melanocy,es averaged 6.0+7.5 in giant, congenital nevi, 2.9+1,9 in small and medium sized congenital novi, 3.1+2.7 in acquired nevi, and 61.5+ 39.4 in malignant, melanomas. Malignant melanomas showed onger intensity of PCNA staining than the other melanocytir nevi.

CONCLUSION:

There was not significant difference of the numter of PCNA-positive cells among the groups of congenital neviind PCNA staining can't be used in prditive measure of malignant. progression and studying mechansm of malignancy in giant congenital nevi. But, PCNA staining is considered as an useful method in differentiat,ing malignant melanoma from mllanocytic nevi.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Piel / Antígeno Nuclear de Célula en Proliferación / Melanoma / Nevo / Nevo Pigmentado Tipo de estudio: Estudio pronóstico / Estudio de tamizaje Idioma: Coreano Revista: Korean Journal of Dermatology Año: 1994 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Piel / Antígeno Nuclear de Célula en Proliferación / Melanoma / Nevo / Nevo Pigmentado Tipo de estudio: Estudio pronóstico / Estudio de tamizaje Idioma: Coreano Revista: Korean Journal of Dermatology Año: 1994 Tipo del documento: Artículo