Evidence of Inflammation in Parkinson’s Disease and Its Contribution to Synucleinopathy
Journal of Movement Disorders
;
: 1-14, 2022.
Artículo
en Inglés
| WPRIM
| ID: wpr-915736
ABSTRACT
Accumulation of alpha-synuclein (αSyn) protein in neurons is a renowned pathological hallmark of Parkinson’s disease (PD). In addition, accumulating evidence indicates that activated inflammatory responses are involved in the pathogenesis of PD. Thus, achieving a better understanding of the interaction between inflammation and synucleinopathy in relation to the PD process will facilitate the development of promising disease-modifying therapies. In this review, the evidence of inflammation in PD is discussed, and human, animal, and laboratory studies relevant to the relationship between inflammation and αSyn are explored as well as new therapeutic targets associated with this relationship.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Journal of Movement Disorders
Año:
2022
Tipo del documento:
Artículo
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