Amyotrophic Lateral Sclerosis - Cell Based Therapy and Novel Therapeutic Development
Experimental Neurobiology
;
: 207-214, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-91757
ABSTRACT
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease, characterized by the predominant loss of motor neurons (MNs) in primary motor cortex, the brainstem, and the spinal cord, causing premature death in most cases. Minimal delay of pathological development by available medicine has prompted the search for novel therapeutic treatments to cure ALS. Cell-based therapy has been proposed as an ultimate source for regeneration of MNs. Recent completion of non-autologous fetal spinal stem cell transplant to ALS patients brought renewed hope for further human trials to cure the disease. Autologous somatic stem cell-based human trials are now in track to reveal the outcome of the ongoing trials. Furthermore, induced pluripotent stem cell (iPSC)-based ALS disease drug screen and autologous cell transplant options will broaden therapeutic options. In this review paper, we discuss recent accomplishments in cell transplant treatment for ALS and future options with iPSC technology.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Regeneración
/
Médula Espinal
/
Células Madre
/
Tronco Encefálico
/
Enfermedades Neurodegenerativas
/
Trasplantes
/
Células Madre Pluripotentes
/
Células-Madre Neurales
/
Mortalidad Prematura
/
Esperanza
Límite:
Humanos
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS