Regulation and Function of the Peg3 Imprinted Domain
Genomics & Informatics
;
: 105-113, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-91763
ABSTRACT
A subset of mammalian genes differ functionally between two alleles due to genomic imprinting, and seven such genes (Peg3, Usp29, APeg3, Zfp264, Zim1, Zim2, Zim3) are localized within the 500-kb genomic interval of the human and mouse genomes, constituting the Peg3 imprinted domain. This Peg3 domain shares several features with the other imprinted domains, including an evolutionarily conserved domain structure, along with transcriptional co-regulation through shared cis regulatory elements, as well as functional roles in controlling fetal growth rates and maternal-caring behaviors. The Peg3 domain also displays some unique features, including YY1-mediated regulation of transcription and imprinting; conversion and adaptation of several protein-coding members as ncRNA genes during evolution; and its close connection to human cancers through the potential tumor suppressor functions of Peg3 and Usp29. In this review, we summarize and discuss these features of the Peg3 domain.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Genes Supresores de Tumor
/
Genoma
/
Impresión Genómica
/
Desarrollo Fetal
/
Alelos
/
Factor de Transcripción YY1
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Genomics & Informatics
Año:
2014
Tipo del documento:
Artículo
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