Immunomodulator use in paediatric severe sepsis and septic shock
Annals of the Academy of Medicine, Singapore
;
: 765-772, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-921072
ABSTRACT
INTRODUCTION@#The use of drugs that modulate the immune system during paediatric severe sepsis and septic shock may alter the course of disease and is poorly studied. This study aims to characterise these children who received immunomodulators and describe their clinical outcomes.@*METHODS@#This is a retrospective chart review of patients with severe sepsis and septic shock admitted into the paediatric intensive care unit (PICU). Clinical, haematological and outcome characteristics of patients with or without exposure to immune-modulating drugs were compared. Primary outcome was PICU mortality; secondary outcomes were 28-day ventilator-free days (VFD) and intensive care unit-free days (IFD). Univariate and multivariable analyses were performed for these outcomes.@*RESULTS@#A total of 109 patients with paediatric severe sepsis or septic shock were identified. Of this number, 47 (43.1%), 16 (14.7%) and 3 (2.8%) patients received systemic corticosteroids, intravenous immunoglobulins and granulocyte colony stimulating factor, respectively. Patients who received immune-modulating drugs were more likely to require invasive ventilation (38/54 [70.4%] versus 26/55 [47.3%], @*CONCLUSION@#Immune-modulating drugs were frequently used in paediatric severe sepsis and septic shock. Patients who received these drugs seemed to require more PICU support. Further studies are required to examine this association thoroughly.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Choque Séptico
/
Unidades de Cuidado Intensivo Pediátrico
/
Estudios Retrospectivos
/
Sepsis
/
Factores Inmunológicos
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
Límite:
Niño
/
Humanos
Idioma:
Inglés
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2021
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS