Does pulmonary metastasectomy of colorectal metastases translate to better survival? A systematic review
Annals of the Academy of Medicine, Singapore
;
: 773-781, 2021.
Artículo
en Inglés
| WPRIM
| ID: wpr-921073
ABSTRACT
INTRODUCTION@#Surgical resection of the primary and metastatic tumour is increasingly recommended in suitable patients with metastatic colorectal cancer (CRC). While the role of metastasectomy is well studied and established in colorectal liver metastasis, evidence remains limited in pulmonary metastases. This systematic review was conducted to examine the current evidence on the role of lung metastasectomy (LUM) in CRC.@*METHODS@#Three databases were systematically searched, to identify studies that compared survival outcomes of LUM, and factors that affected decision for LUM.@*RESULTS@#From a total of 5,477 records, 6 studies were eventually identified. Two papers reported findings from one randomised controlled trial and 4 were retrospective reviews. There was no clear survival benefit in patients who underwent LUM compared to those who did not. When compared against patients who underwent liver metastasectomy, there was also no clear survival benefit. Patients who underwent LUM were also more likely to have a single pulmonary tumour, and metachronous disease.@*CONCLUSION@#The evidence suggests a role for LUM, but is limited by inherent selection bias in retrospective reviews, and the single randomised clinical trial performed was not completed. More prospective studies are required to understand the true effect of LUM on outcomes in metastatic CRC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neumonectomía
/
Pronóstico
/
Neoplasias Colorrectales
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
Tasa de Supervivencia
/
Estudios Retrospectivos
/
Metastasectomía
/
Neoplasias Hepáticas
/
Neoplasias Pulmonares
Tipo de estudio:
Estudio observacional
/
Estudio pronóstico
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2021
Tipo del documento:
Artículo
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